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Because Tirzepatide slows gastric emptying, some patients experience nausea, discomfort, or digestive issues especially during dose escalation

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10.3390/nu11123022 [DOI] [PMC free article] [PubMed] [Google Scholar] Kheirouri S., Valiei F., Taheraghdam A.-A

NG2-glia in the perivascular space can themselves damage the BBB by disrupting astrocyte end-feet and the tight junction integrity of endothelial cells, leading to altered vascular permeability and related central nervous system inflammation [67]

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