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Conversely, in cancer stem cells, the CPT1A/c-Myc feedback loop activates the NRF2/GPX4 axis and downregulates ACSL4, thereby suppressing ferroptosis and potentially diminishing immunotherapeutic response (147)

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Though VIP can trigger mast-cell degranulation in isolation, within the nervous system, it appears to reprogram mast cells toward a non-degranulating phenotype, offering paradoxical protection rather than harm