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KRAS mutant cancer cell lines (HCT116 and Panc-1) were more sensitive to GSTO1 inhibition (Supplementary Table 25)

Nov 17: AstraZeneca scored a first-in-class approval for its pan-AKT inhibitor capivasertib as a treatment for adults with hormone receptorpositive and HER2-negative locally advanced or metastatic breast cancer whose tumors also have PIK3CA, AKT1 or PTEN mutations

It also suggests that air pollution contributes to new-onset asthma

David Walton

Nicotinamide prevents sweet beverage-induced hepatic steatosis in rats by regulating the G6PD, NADPH/NADP+ and GSH/GSSG ratios and reducing oxidative and inflammatory stress

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