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In certain embodiments, the pharmacokinetics of the otic formulations or compositions described herein are determined by injecting the formulation on or near the round window membrane of a test animal (including by way of example, a guinea pig, a chinchilla, or a rat)

In addition, for longer storage, hold it at -20 C

Relationships between protein degradation, cellular senescence, and organismal aging

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FOXO4-DRI is designed to competitively disrupt this binding