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In aged mice, FOXO4-DRI treatment restored fur density, improved renal function, and increased physical activity levels, demonstrating functional rejuvenation through targeted senescent cell clearance

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First, Gln undergoes catalysis by glutaminase (GLS), generating glutamate (Glu), which contributes to the tricarboxylic acid (TCA) cycle by producing alpha-ketoglutarate (-KG), a carbon source for synthesizing lipids, glucose, and nucleotides [4]

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