This combination of lowered serum IGF-1 and increased GH secretion leads to increased insulin resistanceas in the systemic deletion but also developed glucose intolerance [129, 209]
doi:10.1016/j.neulet.2017.07.059
Hablitz LM, Pl V, Giannetto M, Vinitsky HS, Stger FF, Metcalfe T, et al
Cellular senescence in brain aging and neurodegeneration

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Establishment of protocols for global metabolomics by LC-MS for biomarker discovery