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Methyltransferase 3 (METTL3)-mediated N6-methyladenosine (m6A) modification is another cancer-promoting mechanism that protects cells from ferroptosis by increasing PBX1 mRNA stability, which in turn increases GCH1 expression and inhibits ferroptosis through the GCH1-BH4 axis [81]

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Ganguli SC, Ramzan NN, McKusick MA, Andrews JC, Phyliky RL, Kamath PS

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Notably, SETDB1 links ferroptosis to EMT induction as a secondary effect, while USP2 directly drives ferroptosis as a profibrotic mechanism