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It was designed to isolate the fat-metabolising activity localised to the C-terminal region of human growth hormone, while removing the receptor binding responsible for GHs growth-promoting and insulin-antagonistic effects

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This effect was associated with mild edema of the lamina propria and diffuse mild-to-intermediate edema of the submucosa, with collagen formation, one week later on day 10 after ligation (Figure 25A)