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The plates were washed twice with 1 PBS before counterstaining with DAPI diluted 1:1000 in 1 PBS for five minutes followed by 2 washes in 1 PBS

Laboratory investigations have examined its 99% purity, verified through HPLC and mass spectrometry, and documented its receptor selectivity profile

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There is growing consensus regarding their pathophysiology and management, but more work is needed to elucidate the relationships between irAEs and treatment outcomes, specific biomarkers that clinch an irAE diagnosis, the impact of tailored immunosuppression on ICI outcomes, and the management of steroid-refractory irAEs

In the canonical pathway, inhibitor of B (IB) sequesters the RelA/p50 form of NF-B in the cytosol, thereby preventing nuclear translocation

doi:10.1007/s10620-019-05646-y Khaleghi S, Ju JM, Lamba A, Murray JA