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It has to be mentioned that KO mice for IGF-1 gene are not viable and studies in such mice have to be done in the first days of life, and thus results are not very conclusive as metabolism is not properly established at this stage [129, 228]

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When the intestinal barrier breaks down, bacterial products and undigested proteins enter the bloodstream, triggering immune activation that can worsen autoimmune responses throughout the body

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ISP or Intercellular Sigma Peptide, is a recently found peptide that has allowed the inhibition of inhibitory proteins found in scar tissue

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