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[42] Its concentration in wine can be determined by UPLC-MRM mass spectrometry

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While this process is often associated with low-oxygen environments, it also occurs under aerobic conditions in metabolically active tissues such as the brain, heart, and resting skeletal muscle, where lactate dehydrogenase (LDH) facilitates the reversible conversion of pyruvate into lactate in the cytoplasm [3, 4]

In addition to gluconeogenesis, evidence from serum or plasma suggests that fasting stress forces the human body to utilize various non-glucose metabolites, such as conversion of 3-hydroxybutyrate (3-HB) into acetyl-CoA, as energy sources 15,16