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Spermatidic giant cells were observed in monkeys after 6-month treatment at 30 mg/kg/day in addition to vacuolation of seminiferous tubular epithelium

By repressing cardiac peroxisome proliferator-activated receptor-, miR-199a facilitates a metabolic shift from a predominant reliance on fatty acid utilization toward an increased reliance on glucose metabolism, which leads to lethal heart failure (36)

DOX caused significant increases in the number of centronucleated myofibers by approximately 150%, reflecting muscle regeneration in response to injury

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The role of oxidative stress on the pathogenesis of Graves disease

Histologically, reduced pigmentation in the basal layer is observed, along with an absence of melanocytes in the lesions, which can be confirmed by specific immunohistochemical techniques, such as staining for HMB-45 or S100 proteins