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These oxygen-derived free radicals can initiate lipid peroxidation within cellular membranes, ultimately leading to renal tubular necrosis (Singh et al
The microbiota in long COVID
It enhances endogenous antioxidant defenses by increasing glutathione levels, a crucial intracellular antioxidant
This sets the stage for neuroinflammation, which amplifies oxidative stress and excitotoxicity, as discussed in subsequent sections
For example, icariin, a natural compound, has been shown to protect bone marrow mesenchymal stem cells from iron overload-induced dysfunction by modulating these pathways, thereby enhancing mitochondrial function and reducing apoptosis (91)