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In certain embodiments, the formulations or compositions are cross-linked by one or more agents to alter or improve the properties of the formulation or composition

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Later, this definition was extended to include essentially similar protective effects outside the gastrointestinal tract involving the lesions of different organs (cytoprotection-organoprotection)

Elimination is non-linear and dose dependent due to saturation of renal tubular reabsorption, with a half life of 3-10 hrs at low doses & up to 15 hrs at higher doses