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United States Patent Office: 16

, 290 , 17576-17586, doi: Hofbauer, S

ACSL4 acylates AA, and subsequently, LPCAT3 catalyzes the acylated AA to membrane PL, which raises the oxidation of membrane-sensitive fatty acids such as PUFA, ultimately leading to lipid peroxidation [73]

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To investigate the mechanism in detail, we next determined the expression of the TSS pathway enzymes with excess hemin, which significantly reduced the expression of CBS, but not that of CSE (Fig