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Their mechanisms of action are summarized in Figure 3 , and the classification, molecular targets, and known resistance mechanisms are listed in Table 1

The Nrf2 signaling pathway responds to oxidative stress by upregulation of antioxidants like glutathione (GSH) to compensate the stress insult and re-establish homeostasis

The information in this guide summarizes published research literature and is provided for educational and reference use

Tesamorelin is a well-studied alternative with a stronger clinical evidence base from formal trials

Strenuous exercise has resulted in increases in the inflammatory marker C-reactive protein (CRP) to levels comparable to those seen in cardiovascular disease states 12

Most patients tolerate the treatment well