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Notably, increased NAD+ levels also activate NAD+dependent signaling pathways such as sirtuins (SIRT1/SIRT3), further enhancing mitochondrial biogenesis and energy metabolism

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Some studies have shown that metformin can reduce the absorption of vitamin B12 in 30% of people with type 2 diabetes (Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy)

Anemia and its association with Helicobacter pylori infection among adult dyspeptic patients attending Wachemo University Nigist Eleni Mohammad Memorial Referral Hospital, Southwest Ethiopia: A cross-sectional study

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