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In addition, -syn and p--syn levels increased in the insoluble fraction of RIPA following hypoxic treatment for 7 days, suggesting that hypoxia promoted the phosphorylation of -syn and long-term hypoxia promoted -syn to form abnormal aggregates in the insoluble fraction (Fig

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Although the aforementioned studies have demonstrated that targeting the necroptosis pathway is a viable strategy in AML, the clinical relevance of the RIPK1/RIPK3/MLKL axis remains unclear (135137)

doi: 10.3390/pharmaceutics16030441 12