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Iron accumulation and lipid peroxidation in the aging retina: implication of ferroptosis in age-related macular degeneration

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used asiatic acid to treat RA-FLSs and reported that increasing concentrations of asiatic acid significantly increased the expression of the Nrf2/HO-1 protein and inhibited downstream NF-B signalling, which in turn increased the expression of proapoptotic proteins (Bax and caspase-3) and decreased the expression level of the antiapoptotic protein Bcl-2, increasing the level of apoptosis and inhibiting the proliferation and cloning of RA-FLSs

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Topical Creams: Continued use of prescription-strength lightening creams (like hydroquinone or retinoids) can help manage and prevent new pigment from forming

Wall, R