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While this M1/M2 classification oversimplifies microglial diversity, it remains useful for distinguishing functional profiles [124, 125]

When to increase dose Consider increasing if: Minimal response after 4-6 weeks at current dose No side effects at current dose Current dose below the higher end of recommended range Goals not being met with conservative approach Increase gradually, typically by 25-50% at a time

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Am J Clin Nutr 106, 878887.CrossRefGoogle Scholar et al

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