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A global reduction in 5-methylcytosine (5mC) levels, indicative of widespread hypomethylation, has been reported in astrocytes of postmortem AD brains, potentially leading to aberrant gene activation 25

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Preclinical research introduced FOXO4-DRI as a targeted approach for studying senescent cell survival mechanisms by modulating transcription factor interactions rather than global cytotoxic activity

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87 , E36E46 (2004)