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The expression of PGC-14 in myotubes did not affect the regulation of many classic PGC-1 targets, including mitochondrial OXPHOS genes

Diese synergistische Herangehensweise zielt nicht auf einen einzelnen Effekt ab, sondern auf die Untersttzung mehrerer miteinander verbundener Mechanismen vom Zellschutz ber die Stoffwechselaktivitt bis hin zur Erhaltung der Hautbarriere

This modification inhibits its phosphorylation and deactivates the AMPK pathway, resulting in diminished matrix synthesis, increased degradation, reduced autophagy, and accelerated cellular senescence

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3f and Supplementary Table 1)