It is found in human plasma, saliva, and urine, and plays a role in tissue repair, skin health, and cellular regeneration
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In addition, the oldest orphan nuclear receptor estrogen-related receptor (ERR), an important regulator of metabolic gene transcription and innate immune function, including those induced by toll-like receptor (TLR) and antimicrobial activities against intracellular bacterial infection [147], facilitated post-translational activation of autophagy by deacetylating various autophagy-related proteins, including ATG5, BECN1, and ATG7
One key consequence is the compromise of intestinal barrier integrity, often referred to as a leaky gut, which increases permeability to microbial-derived components such as LPS