Through its peroxidase activity, PRDX6 directly reduces PL-OOHs, providing antioxidant defense even in the absence of GPX4
Neuropsychopharmacology 29, 795798 (2004)
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Similarly, pS6K levels were significantly upregulated in HG-treated HRMC cells and improved by HU treatment (Figures 7C, D)
Its additional effects on the dopaminergic system through neurotransmitter modulation add further interest
Generation of knockout, knockdown and cDNA overexpression cell lines sgRNAs (oligonucleotide sequences are indicated below) were cloned into lentiCRISPR-v2 (Addgene) (for GCLC )or into lentiCRISPR-v1 (Addgene) (for SLC25A39 ) linearized with BsmBI by T4 ligase (NEB)
