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However, it has been proposed that activation of this common pathway through physiological signals results in term labor, while preterm labor might occur from spontaneous activation of isolated aspects of the common pathway by the presence of pathological conditions that may be induced by multiple causes [238] or risk factors

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These include upregulating the Bax/Bcl-2 ratio in the mitochondria, 357 inducing HIF-1 degradation, 358 and involving with NF-B pathway 359 (Fig

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