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[7] [9] Patients with a history of oxalate nephrolithiasis (kidney stones) or hyperoxaluria should avoid high-dose vitamin C administration, as ascorbic acid is metabolized to oxalate, which may precipitate stone formation or exacerbate renal impairment

This pathway of cell death is intricately connected to various metabolic functions within the cell, such as lipid metabolism, iron regulation and the management of reactive oxygen species (ROS), underscoring its important impact on cellular health and disease pathogenesis (3133)

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