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They can include a low-fiber diet, dehydration, lack of physical activity, certain medications, and medical conditions such as irritable bowel syndrome or hypothyroidism

Individual heavy atoms RMSD for the 6 active site residues, backbone RMSD for the whole protein, backbone RMSD for the 17 active site residues, and RMSD for ligand heavy atoms were calculated for all MD simulations

[137] Laboratory [edit] The complete laboratory synthesis of B 12 was achieved by Robert Burns Woodward [138] and Albert Eschenmoser in 1972

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In Achilles transection and ligament injury models, it counteracts corticosteroid impairment, elevates collagen deposition, and increases biomechanical strength