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The rationale behind combining them is rooted in cellular metabolism

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These senescent cells (SnCs) are characterized by permanent growth arrest, enhanced ROS synthesis, resistance to apoptosis, and a permanent low-level release of pro-inflammatory molecules

J Clin Gastroenterol 38:S86S90 Uttra AM, Shahzad M, Shabbir A, Jahan S (2018) Ephedra gerardiana aqueous ethanolic extract and fractions attenuate Freund Complete Adjuvant induced arthritis in Sprague Dawley rats by downregulating PGE2, COX2, IL-1, IL-6, TNF-, NF-kB and upregulating IL-4 and IL-10

doi: 10.1084/jem.20132451 80 Lettieri-BarbatoD.CannataS

[DOI] [PubMed] [Google Scholar] 251.Leon Bradlow H., Zumoff B., Gallagher T.F., Hellman L