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Furthermore, owing to different reasons, a considerable number of cancer patients did not respond to these therapeutics efficiently (8,9)

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In some embodiments, the otic formulation or composition comprises about 15% by weight of the poloxamer

Interestingly, our in silico database search of enriched ABR genes had hits to the Gram-negative bacteria family of Enterobacteriaceae and in some cases specific genera of Salmonella , Escherichia , Klebsiella , Shigella , Enterobacter and Citrobacter