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All experiments involving animals were carried out in strict compliance with the laboratory animal care and use guidelines of The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University

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Under conditions such as inflammation or oxygen deprivation, SphK1 activity rises, leading to increased S1P concentrations in red blood cells (Sassoli et al., 2019)

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Abdominal subcutaneous injection is commonly used for convenience

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International Journal of Molecular Sciences , 26 (6), 2691

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During ischemic conditions, myocardial LC levels fall rapidly

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