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10.1186/s13020-024-00918-w 19 ChenY

Interestingly, these seemingly dichotomous effects of E2 on intracellular bioenergetics could be a result of differential receptor activation, as E2 was found to inhibit F0F1-ATP synthase activity via non-genomic mechanisms in a human osteoclastic cell line (FLG 29.1 cells) (200)

Similarly, decreased lactylation of malate dehydrogenase 2 at K241, coupled with reduced lactate production, leads to elevated levels of GSH and GPX4, thereby alleviating ferroptosis and improving mitochondrial function in myocardial IRI (120)

ENCODE Project Consortium An integrated encyclopedia of DNA elements in the human genome

Onions contain two specific compoundsquercetin and propyl disulfidethat have been shown in some laboratory studies to inhibit an enzyme called thyroid peroxidase (TPO)

Part of the drug definition may relate to marketed uses in certain health conditions