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Tan DQ, Suda T

Beyond intracellular sensing via NODs, PGN-derived fragments function as potent signals that trigger the assembly of the NOD-like receptor protein 3 (NLRP3) inflammasome, leading to the maturation and secretion of IL-1

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This also requires an agreement on the allocation of intellectual property

10.1016/j.cell.2022.06.003 154 SuG.YangW.WangS.GengC.GuanX

By integrating these disparate elements, our work emphasises the necessity of a holistic approach to diagnosing, researching, and treating ME/CFS, urging the scientific community to reconsider the diseases complexity and the multifaceted approach required for its study and management