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This mechanism was documented in humans in 1984 by Bowers and confirmed in multiple clinical studies (Nass et al., J Clin Endocrinol Metab 2008)

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38-40 In addition, IC/BPS patients have significantly more pain, sleep dysfunction, catastrophizing, depression, anxiety, stress, social functioning difficulties and sexual dysfunction than do non-IC/BPS age-matched women

Trajkovska, V

Methylmalonic acid (MMA): A more sensitive marker of B12 function

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